Mikael Brisslert Selected Research

geranylgeranyltransferase type-I (protein geranylgeranyltransferase)

1/2022	Rho-GTPase dependent leukocyte interaction generates pro-inflammatory thymic Tregs and causes arthritis.
1/2019	Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions.
2/2011	Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice.

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Mikael Brisslert Research Topics

Disease

11	Rheumatoid Arthritis 01/2019 - 01/2009
10	Arthritis (Polyarthritis) 01/2022 - 03/2006
5	Inflammation (Inflammations) 01/2022 - 03/2006
3	Neoplasms (Cancer) 12/2013 - 03/2011
2	Experimental Arthritis 10/2011 - 01/2007
1	Epstein-Barr Virus Infections 12/2013
1	Autoimmune Diseases (Autoimmune Disease) 12/2013
1	Viremia 03/2013
1	Infections 03/2013
1	Atherosclerosis 11/2011
1	Synovitis 10/2011
1	Necrosis 03/2011
1	Hyperplasia 03/2011
1	Human Influenza (Influenza) 01/2010
1	Sepsis (Septicemia) 10/2009
1	Hypersensitivity (Allergy) 03/2006
1	Gout 03/2006
1	Edema (Dropsy) 03/2006

Drug/Important Bio-Agent (IBA)

5	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2010
3	geranylgeranyltransferase type-I (protein geranylgeranyltransferase)IBA 01/2022 - 02/2011
3	SurvivinIBA 01/2017 - 07/2015
3	RNA (Ribonucleic Acid)IBA 11/2014 - 03/2006
3	methylated bovine serum albumin (MBSA)IBA 11/2014 - 10/2011
3	AntigensIBA 01/2013 - 01/2010
3	Rituximab (Mabthera)FDA Link 10/2010 - 01/2009
2	CytokinesIBA 01/2019 - 06/2015
2	InterleukinsIBA 06/2015 - 03/2011
1	rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA 01/2022
1	CateninsIBA 01/2022
1	Guanosine Triphosphate (GTP)IBA 01/2019
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2019
1	Oncogene Proteins (Oncogene Protein)IBA 07/2015
1	Interleukin-17 (Interleukin 17)IBA 06/2015
1	Small Interfering RNA (siRNA)IBA 11/2014
1	Myosins (Myosin)IBA 11/2014
1	src-Family KinasesIBA 11/2014
1	CalciumIBA 11/2014
1	S100 Calcium-Binding Protein A4IBA 11/2014
1	AutoantibodiesIBA 12/2013
1	Immunoglobulins (Immunoglobulin)IBA 12/2013
1	LigandsIBA 03/2013
1	FucosyltransferasesIBA 03/2013
1	SelectinsIBA 03/2013
1	Cycloheximide (Cicloheximide)IBA 03/2013
1	AntibodiesIBA 01/2013
1	flt3 ligand protein (flt3 ligand)IBA 01/2013
1	LipidsIBA 11/2011
1	Toll-Like Receptors (Toll-Like Receptor)IBA 11/2011
1	Pattern Recognition ReceptorsIBA 11/2011
1	fms-Like Tyrosine Kinase 3IBA 10/2011
1	Sunitinib (Sutent)FDA Link 10/2011
1	Interleukin-6 (Interleukin 6)IBA 09/2011
1	L-SelectinIBA 09/2011
1	Glycoproteins (Glycoprotein)IBA 03/2011
1	Transforming Growth Factors (Transforming Growth Factor)IBA 03/2011
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 03/2011
1	CitrullineIBA 06/2010
1	homocitrullineIBA 06/2010
1	Peptides (Polypeptides)IBA 06/2010
1	Polysaccharides (Glycans)IBA 01/2010
1	VaccinesIBA 01/2010
1	Immunoglobulin G (IgG)IBA 01/2010
1	AfluriaIBA 01/2010
1	Pneumococcal Vaccines (Pneumococcal Polysaccharide Vaccine)IBA 01/2010
1	CarbohydratesIBA 01/2010
1	AcetaldehydeIBA 01/2007
1	Transcription Factors (Transcription Factor)IBA 01/2007
1	Ethanol (Ethyl Alcohol)IBA 01/2007
1	Biological ProductsIBA 03/2006
1	Nucleic AcidsIBA 03/2006
1	Uric Acid (Urate)IBA 03/2006
1	SuspensionsIBA 03/2006

Therapy/Procedure

2	Therapeutics 09/2012 - 10/2009
1	Intraperitoneal Injections 01/2013
1	Intra-Articular Injections 06/2010